Additionally, several reports have implied that XBP1s may play a cytoprotective role against toxic aggregates in a variety of Aβ-associated AD models, including Aβ-expressing Drosophila and Aβ-treated cultured mammalian neurons [121], and also in tauopathy-related AD models, including transgenic Drosophila and C. elegans expressing aggregation-prone mutant tau variants [122,123]. This evidence concerns the gene MAPT and Alzheimer disease.