CASP3 and acute myeloid leukemia: However, in studies on the action of rupatadine, ebastine, and loratadine in relation to acute myeloblastic leukemia cells, the cytotoxicity of these compounds consisted of bidirectional, mitochondrial-lysosomal action, ROS generation, and reduction of mitochondrial metabolic activity, which led to the activation of caspase 3 and 7 and induction of the apoptosis pathway [62].