AR and colon adenocarcinoma: As previously reported [28], human HT29 colon adenocarcinoma cells stably expressing SDC2 (HT29-SDC2) showed upregulation of the mRNA expression of MMP-7 (Figure S1), and their conditioned media showed increased MMP-7 enzymatic activity to cleave an exogenous substrate (Mca-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2, Mca-PLA-Nva-Dap(Dnp)-AR-NH2) (Figure 1A).