Interestingly, a synthetic peptide (S2-P) corresponding to a portion of the SDC2 sequence bound the pro-domain of MMP-7 to interrupt the SDC2–MMP-7 interaction and block the activation of pro-MMP-7, and this inhibited the tumorigenic activities of colon cancer cells [11]. The gene discussed is MMP7; the disease is malignant colon neoplasm.