Since the interaction of SDC2 with MMP-7 is important to regulate cancer activity [11,26], and 50 nM of S2P showed anticancer activity both in vitro and in vivo [30], we further investigated whether 50 nM of S2-D and S2-FE could inhibit the cancer activity of HT29-SDC2 cells (Figure 4). This evidence concerns the gene SDC2 and cancer.