In a mouse model of acute vascular inflammation and deficient for P2Y1-R in the whole body (P2Y1-KO), a reduction in leucocyte recruitment was shown in the femoral artery after local subcutaneous injection of both tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β), two inflammatory cytokines [7]. The gene discussed is TNF; the disease is inflammation.