To evaluate whether the expression of some integrin subunits was modified by SPARC in PCa cells, the levels of the integrin subunits αv, α5, β1, β3, β4, and β5 were evaluated through Western blot in PC3 cells with the stable knockdown of SPARC (shSPARC), and LNCaP cells with stable SPARC overexpression (SPARC_HA). Here, SPARC is linked to posterior cortical atrophy.