For example, we observed that knocking down SPARC induces changes in cell polarity, increases the expression of E-cadherin, and decreases the expression of ZEB1, N-cadherin, and vimentin, while decreasing the invasive and migratory capacity of PCa cells, as evaluated by the wound-healing and transmigration assays [11]. This evidence concerns the gene SPARC and posterior cortical atrophy.