TGFB1 and neoplasm: However, a study analyzing biopsies of eight early OS tumor tissues paired to their normal adjacent tissues, miR-202 appeared to be significantly upregulated in the tumor tissues, while miR-202 was found to play a role in chemoresistance by inhibiting apoptosis in TGF-β1-treated OS cell lines through targeting the suppressor gene PDCD4 [73].