LRP6 and hepatocellular carcinoma: Similarly, the low-density lipoprotein receptor-related protein 6 (LRP6) was demonstrated to be a direct target of miR-202 where the latter suppressed the expression of LRP6 by binding to the 3′-untranslated region (UTR) of its mRNA, while overexpression of miR-202 in HCC cells suppressed LRP6, reducing cell proliferation and tumorigenicity [29].