Non-canonical roles for ORAI1 and STIM1 have been identified in diffuse large B cell lymphoma cells, where silencing of the ORAI1 and STIM1 expression impairs migratory behavior, yet this effect was not observed when the ORAI1-mediated Ca2+ influx was inhibited using a pharmacological inhibitor [16]. This evidence concerns the gene ORAI1 and diffuse large B-cell lymphoma.