Furthermore, Wdr26−/− zebrafish exhibited profound anemia likely due to defective erythropoiesis, a phenotype also reported in the initial study on Maea−/− mouse embryos [93,106]; however, rather than observing defects in erythroblastic island adhesion or macrophage differentiation, the Wdr26 knockout animals had deficiencies in the nuclear opening of erythroblasts. This evidence concerns the gene MAEA and anemia.