Furthermore, Wdr26−/− zebrafish exhibited profound anemia likely due to defective erythropoiesis, a phenotype also reported in the initial study on Maea−/− mouse embryos [93,106]; however, rather than observing defects in erythroblastic island adhesion or macrophage differentiation, the Wdr26 knockout animals had deficiencies in the nuclear opening of erythroblasts. Here, MAEA is linked to anemia (phenotype).