The Cancer Genome Atlas (TCGA) Research Network identified four molecular subgroups of endometrial carcinoma: copy-number-low/p53-wild-type (p53wt), POLE-mutated/ultramutated (POLEmt), microsatellite-instability/hypermutated (MSI) and copy-number-high/p53-mutated (p53mt) in 2013 [33]. This evidence concerns the gene POLE and endometrial carcinoma.