AGT and renal fibrosis: HIF-1α has been reported to be involved in metabolic, neoplastic, and fibrotic diseases such as myocardial fibrosis, hepatic fibrosis, and renal fibrosis [23,24,25,26,27] HIF-1α has been reported to be involved in the activation of the NOTCH signaling pathway in diseases such as Ang II-induced myocardial fibrosis and odontogenic keratotic cysts [28,29].