Compared with the control, in the periphery, higher levels of soluble TNF receptor2 (sTNFR2), IL-6, monocyte chemoattractant protein-1 (MCP-1) were identified in MCI, and levels of high-sensitivity CRP (hs-CRP), IL-6, sTNFR1, sTNFR2, IL-1β increased in AD. This evidence concerns the gene CCL2 and Alzheimer disease.