For instance, miR-375 regulates the occurrence and development of colorectal cancer, knee osteoarthritis, acinar cells inflammation, and nasopharyngeal carcinoma by targeting the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), autophagy-related 2B (ATG2B), autophagy-related 7 (ATG7), and pyruvate dehydrogenase kinase 1 (PDK1) genes, respectively [18,19,20,21]. This evidence concerns the gene PIK3CA and osteoarthritis, knee.