IFITM1 and infection: NSP3 interacts with the porcine IFITM1 distributed around the periphery of the nucleus, induces IFITM1 degradation in PRRSV during infection, and counteracts the antiviral function of IFITM1; thus, further analysis of this protein can provide new clues for exploring the mechanisms associated with PRRSV-evading host immune recognition [64].