CD274 and anal carcinoma: Different mechanisms of immune evasion have been studied in penile [11,21,53,54] vulvar [14,18,20,55] and anal cancers [17,19], and included immune checkpoint proteins and exhausted phenotypes for infiltrating-lymphocytes, suggesting that patients with these type of tumors can benefit from anti PD-L1 therapy [9,27,56,57,58,59].