The miR-378 sequence is located at the 5′ end of the PGC-1β mRNA sequence; therefore, this small molecule further silences its targeting genes, such as KLK2, KLK4, KLK6, KLK14, etc. All the results showed that this significantly induced cell apoptosis in the PCa cells, which was proven in cell viability, cell death, and apoptosis assay experiments (p < 0.05) (Figure 6). The gene discussed is KLK4; the disease is posterior cortical atrophy.