Glycyrrhizin and licorice flavonoids suppress cancer initiation through complex effects on macrophages that involve inhibition of high-mobility group box 1 (HMGB1)-TLR4-NF-kB signaling, proinflammatory cytokines, COX-2, and M2 polarization [147,148,149]. The gene discussed is HMGB1; the disease is cancer.