DCLK1 and cancer: These macrophage-derived cancer stem cells express stem-like markers (e.g., leucine-rich repeat-containing G-protein 5 [LGR5], doublecortin-like kinase 1 [DCLK1], epithelial cell adhesion molecule [EpCAM], CD44, and CD133) and markers for dedifferentiation and pluripotency [68,69].