In recent years, studies on the formation of EGFR heterodimers with family partners, or other RTKs, respectively to promote cancer or drug resistance through multiple pathways, including PI3K/AKT/mTOR, Ras/MEK/ERK, and JAK/STAT have been conducted [50,51,52,53,54,55,56,57]. This evidence concerns the gene MAPK1 and cancer.