ACC prognosis can be estimated with good accuracy by using (1) CIMP (CpG island methylation phenotype) clustering [18,19,87], (2) gene expression profiles-based clustering (C1A and C1B) [20], (3) COMBI score (combination of modified GRADE (Grading of Recommendations Assessment, Development and Evaluation) score and genomic alterations) [88], and (4) BUB1B-PINK1-based gene expression [20,22]. The gene discussed is PINK1; the disease is adrenal cortex carcinoma.