Sig27var25 and SigIQvar8 are highly effective at predicting ACC prognosis and progression; both signatures contain component genes predicting poor OS independently of age and tumor stages, for instance SNHG10 and RECQL4 for SigIQvar8 (Table 2) as well as MXD3, BIRC5, and RAB30 for Sig27var25 (Table 1). This evidence concerns the gene RECQL4 and neoplasm.