TGFB1 and adrenal cortex carcinoma: Consistent with this knowledge, Sig25var25 component genes associate with TGFβ signaling (Figure 8), a critical contributor to T-cell exclusion [81]; Sig27var25, SigIQvar8, SigCmbnvar5, SigCmbn_B, as well as Sigpub_BP significantly associate with reductions of CD8+ T and/or NK cells in ACC (Figure 9).