Network views as implemented in oposSOM [19] visualize topological properties of the sample similarity landscapes: The Dme-network topology is virtually one-dimensional, pointing from low methylation in IDH-wt tumours towards highest methylation in GCIMP-O seen in IDH-O type tumours, with IDH-A and GCIMP-low LGG in between, forming a transition range between low and high methylated gliomas (Figure 3b). This evidence concerns the gene IDH2 and central nervous system cancer.