These cells also expressed higher levels of Hes1, a transcription factor that is a target of NOTCH1 signalling, revealing that NOTCH signalling may play a role in malignant transformation in GATA3 overexpressing cells, potentially through c-MYC, which considered a direct target of NOTCH1 in T lymphoblastic leukaemia/lymphoma [22]. The gene discussed is MYC; the disease is lymphoma.