However, the relationship of GATA3 to other genes involved in T-ALL development in humans and mice, including the basic-helix-loop-helix (bHLH) proteins c-MYC, Tal1, and E2A; LIM-only domain proteins (Lmo1 and Lmo2); and the heterodimeric transmembrane receptor NOTCH1, is still unknown [96]. Here, NOTCH1 is linked to acute lymphoblastic leukemia.