ZNF582 and cancer: We then compared ZNF582-AS1 expression in breast cancer (n = 837) versus adjacent normal tissue (n = 105) in TCGA and observed substantial differences, lower ZNF582-AS1 expression in cancer than in normal tissues (Figure 1A), and similar differences were also seen in paired tissue samples, i.e., tumor and normal tissues from the same patients (Figure 1B).