The oncogene Astrocyte elevated gene-1 (AEG-1) is highly expressed in HCC and a galactose-conjugated PAMAM-PEG NP (PAMAM-PEG-Gal) delivering AEG-1 siRNA, in combination with all-trans retinoic acid (ATRA), markedly inhibited growth of orthotopic xenografts of QGY-7703 human HCC cells [28]. The gene discussed is MTDH; the disease is hepatocellular carcinoma.