VEGFA and neoplasm: A similar study conducted with SPIO loaded with siRNA radiolabeled by 131I to specifically target human vascular endothelial growth factor (VEGF), an oncogene playing a pivotal role in tumor angiogenesis and cancer progression, inhibited HepG2 xenografts in nude mice exposed to an external magnetic field with the concomitant downregulation of VEGF [25].