CD274 and neoplasm: In another study of neoadjuvant durvalumab alone or combined with stereotactic body radiation therapy, MPR was achieved independently of PD-L1 tumor status after adjusting for PD-L1 baseline expression assessed by IHC, and no significant changes in PD-L1 expression were observed when comparing pre-treatment and surgical resection tumor specimens in both trial groups and between patients with and without MPR [57].