Glioblastomas (GBMs) are derived from neural cancer stem cells and HOPX regulates the hippocampal stem cell niche through controlling cell survival and apoptosis, but it is downregulated in GBMs in mice; a key finding of this work is that reactivating HOPX causes apoptosis and lowers the tumorigenic ability of GBM cancer stem cells [38]. This evidence concerns the gene HOPX and cancer.