We elected to focus on mTORC1, as it is the signaling gatekeeper for the upstream phosphatidylinositol 3-kinase (PI3K)/ a serine/threonine protein kinase (AKT) and mitogen-activated protein kinase (MAPK) growth pathways [11], and these regulate the expression of a number of glycolytic enzymes for the enhancement of glycolysis and promotion of tumor cell growth [12]. This evidence concerns the gene AKT1 and neoplasm.