Having defined the culture conditions for both neuroblasts and chromaffin cells, inhibitors that interfere with the signaling pathways controlling neuroblast proliferation (ALK, WNT, IGF1, PRC2/EZH2) and/or are known to interfere with neuroblastoma growth affecting epigenetic mechanisms (EZH2, BET, CDK7) were investigated. This evidence concerns the gene DNER and neuroblastoma.