Among the 84 cell motility genes studied here, VIM and ITGB2 were found to be selective targets of SMAD3, and these two genes strongly correlated with the tissue-specific hypoxic gene signature in fibrosarcoma, breast carcinoma and lung adenocarcinoma cancer types, suggesting their regulation by the exacerbated SMAD3 pathway in various tumors. This evidence concerns the gene VIM and fibrosarcoma.