SMAD3 and breast carcinoma: To study the concordance between the proinvasive SMAD3 gene signature and intratumoral hypoxia, we used publicly available RNA sequencing data and assessed the correlation between the expression of RHOB, VIM and ITGB2 and that of known hypoxia-induced genes in lung adenocarcinoma [46], breast carcinoma [45] and fibroblastic sarcoma [47].