Among the 84 cell motility genes studied here, VIM and ITGB2 were found to be selective targets of SMAD3, and these two genes strongly correlated with the tissue-specific hypoxic gene signature in fibrosarcoma, breast carcinoma and lung adenocarcinoma cancer types, suggesting their regulation by the exacerbated SMAD3 pathway in various tumors. The gene discussed is SMAD3; the disease is breast carcinoma.