Recently, interactions between SIRT1 and PGC-1α have attracted much attention in the study of tumorigenesis, as an SIRT1/PGC-1α-dependent increase in mitochondrial biogenesis and OXPHOS enhanced the chemoresistance of colon cancer and metastasis of hepatocellular carcinoma (HCC) [12,13]. The gene discussed is SIRT1; the disease is colonic neoplasm.