PPARGC1A and non-small cell lung carcinoma: Taguchi et al. evaluated mRNA levels of PGC-1α in 28 NSCLC cell lines with different p53 mutational statuses and observed that mRNA levels of PGC-1α were higher in p53 WT cells compared with cell lines harboring p53 loss or missense mutations [30], implying that PGC-1α might be a potential target of WT p53 in NSCLC.