Our experience also shows that HR patients tolerated PT well, even with concurrent single-agent chemotherapy with vinorelbine in 12 of them, and with concurrent temozolomide in one case: none had to interrupt radiation due to major hematological adverse effects, although in one case it was necessary to interrupt concurrent chemotherapy and in two cases G-CSF was administered for leukopenia. This evidence concerns the gene CSF3 and Decreased total leukocyte count.