Under pro-angiogenic stimuli in a tumor context, the endothelial glycolytic rate increases and different glycolytic enzymes (e.g., hexokinase 2 (HK2) and pyruvate kinase (PK)) relocate into migratory cell structures, such as lamellipodia and filopodia, favoring cell migration [9]. The gene discussed is HK2; the disease is neoplasm.