While the effect of different glycolytic enzymes (e.g., PFKFB3, HK2, and PKM2) has been addressed in tumor angiogenesis, the role of glycolytic-branching pathways still remains largely unexplored, including hexosamine biosynthesis (HBP) and the pentose phosphate pathway (PPP) in an angiogenic cancer context. This evidence concerns the gene HK1 and cancer.