MTOR and neoplasm: The activation of mTOR, a serine-threonine kinase, leads to the phosphorylation of eIF4E-binding protein 1 (4E-BP1), which promotes the release of eukaryotic initiation factor (eIF4F), which, in turn, allows for the translation of specific mRNA subsets involved in tumor proliferation, angiogenesis, and survival [103,104].