Consequently, the loss of E-cadherin expression will allow the dissociation and translocation of β-catenin from the cytoplasm to the nucleus, increasing the mobility of neoplastic cells, as well as their local invasion capacity, in addition to being used as an important marker of EMT during tumor progression and metastasis of human and canine PC [146,147,148]. Here, CDH1 is linked to pachyonychia congenita.