Although VEGF and FGF-2 act together to stimulate the recruitment of perivascular cells and formation of functional vasculature [171], FGF-2 is also associated with epithelial and stromal proliferation in different prostate lesions, with an increase in immunoexpression in cases of hyperplasia and metastatic PC, as it induces numerical chromosomal defects and higher DNA breakage [172,173]. Here, FGF2 is linked to pachyonychia congenita.