Activation of the phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB-AKT), and mammalian target of rapamycin (mTOR) signaling pathway, known as PI3K/PKB-AKT/mTOR, is involved in multiple cell-signaling cascades related to tumor survival, initiation, and progression, being also able to decrease the sensitivity of PC cells to targeted therapies [102]. Here, MTOR is linked to pachyonychia congenita.