KRAS and neoplasm: It has been shown that chronic HFD significantly elevated COX-2 levels, leading to the development of extensive inflammation and neoplasm in the KrasG12D/+ pancreas, while pancreatic acinar cell-specific ablation of Cox-2 abolished the effects of HFD on stimulating oncogenic KRAS-induced inflammation, PanIN lesions, and PDAC [12,32].