Compared to the general population, an increased risk was observed for patients with T1DM (IRR = 3.00, 95% CI 1.12, 8.02) and a slight increased risk was observed for T2DM in insulin users (IRR = 1.5, 95% CI 1.0, 2.3) and when comparing insulin-only users to patients with T2DM treated with diet alone (IRR = 1.58, 95% CI 0.72, 3.48) (Table 3). The gene discussed is INS; the disease is type 1 diabetes mellitus.