HP and Constitutional hemolytic anemia due to acanthocytosis: Furthermore, the infrequent (37% of cases) and only mild (average 0.93 g/mL within the normal range of 0.2–2.0 g/dL) haptoglobin decreases under alectinib suggest that hemolysis occurs predominantly in the extravascular compartment, for example in the spleen, where distorted erythrocytes tend to become trapped and destructed, as has also been described for patients with other forms of acquired severe acanthocytosis, e.g., in the context of liver cirrhosis [21,22].