Furthermore, the paucity of disease progression or death, despite the relatively long follow-up for PFS (after 39.5 months median follow-up time in only 3/19 events), the lack of any trend for association between PFS and hemolytic parameters, and the putative pathogenesis of hemolysis in all analyzed patients as a direct toxic effect of alectinib, taken together, argue strongly against a potential prognostic or predictive importance for red blood cell aberrations in metastatic ALK+ NSCLC treated with this drug. The gene discussed is ALK; the disease is non-small cell lung carcinoma.