In SGC7901 and MKN45 (poorly differentiated) GC cell lines, the hypoxic microenvironment increased the expression of MMP-9 and urokinase-type plasminogen activator and decreased the expression of tissue inhibitor of matrix metalloproteinase (TIMP)-1, through HIF-1α-induced upregulation of 67 kDa Laminin receptor (67LR). The gene discussed is HIF1A; the disease is gastric cancer.