Notably, concomitant overexpression of tumor suppressor protein p53 with HIF-1α was correlated with a dismal prognosis in GC patients, where HIF-1α(+)/p53(+) primary gastric tumors were more frequently associated with an undifferentiated, infiltrative, and metastatic phenotype compared to HIF-1α(−)/p53(−) tumors [74]. Here, TP53 is linked to gastric neoplasm.