As an example, the transforming growth factor-beta (TGF-β), is a key cytokine that in normal conditions induces tolerance and suppresses inflammation and in the early phases of tumorigenesis acts as a cytostatic tumor suppressive agent acting through p21 and p27 CDKI expression and inducing cancer cell apoptosis (Table 1) [58,59]. This evidence concerns the gene TGFB1 and neoplasm.