Uncontrolled inflammation perpetuates the carcinogenesis via modulation of the tumor microenvironment (TME) with the secretion of pro-inflammatory mediators (TNF-alfa, IL-6) and angiogenesis factors, chemotaxis of immune-tolerant tumor-associated macrophages (TAMs), and other stromal auxiliary elements [50,51,52]. The gene discussed is IL6; the disease is neoplasm.