IFNG and neoplasm: Further experiments performed mainly in tumor-bearing mice demonstrated that RT induced IFN-γ production within the primary tumor, which was followed by increased intratumoral T-cell trafficking through increased expression of adhesion molecules by endothelial cells (including intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E selectin) and in the presence of high levels of T-cell chemoattractants [9,11,12,13].