While ATP is regarded as a key mediator of RT-induced anti-tumor immunity, known to stimulate DCs to differentiate, to process engulfed tumor antigens, and to cross-present them to naïve T cells, in the TME it is rapidly catabolized into adenosine by the actions of ectonucleotidases, mainly CD39 and CD73 [51]. This evidence concerns the gene ENTPD1 and neoplasm.