TNF and Crohn disease: Over the last decade, the accuracy and reliability of SNDS have been evaluated for a very large range of medical conditions, in patients with prosthetic heart valves [20], in patients with Crohn’s disease [21], in parturient women [22], or for risks associated with exposure to certain treatments, such as cyproterone acetate [23], statins [24], thiopurines, or TNF antagonists [25].