Additionally, since the nucleocytoplasmic transport of HuR depends on the interaction of this RBP with cytoskeletal proteins, the naturally occurring cytoskeletal inhibitors latrunculin A and blebbistatin have shown to exert antitumorigenic properties in human hepatoma cells, by interfering with the intracellular trafficking of HuR and its mRNA cargo [223]. The gene discussed is ELAVL1; the disease is hepatocellular carcinoma.