ETS1 and hepatocellular carcinoma: Moreover, Wilms tumor 1-associated protein (WTAP) drives N6-methyladenosine (m6A) RNA methylation and epigenetic silencing of ETS1, by interfering with HuR-mediated stabilization of ETS1 mRNA, further alleviating the expression of p21 and p27 G2/M checkpoint proteins, which are known downstream effectors of ETS1, and facilitating HCC progression [197].