The HuR promoter region contains a target of NF-kB, to which one of its members—p65/RelA—binds upon the induction of the phosphatidylinositol 3-kinase (PI3K)/AKT signaling route, resulting in the abnormal upregulation of HuR gene expression in gastric tumors [119]. The gene discussed is AKT1; the disease is gastric neoplasm.