In conclusion, even though, in the past few years, great efforts have been carried out, in order to better understand the function of HuR and its regulation in hepatobiliary tumors, further studies are necessary to address the therapeutic potential of HuR inhibitors or, alternatively, a more-personalized treatment based on the selected inhibition of HuR and its RNA or the protein targets in HCC and CCA. This evidence concerns the gene ELAVL1 and cholangiocarcinoma.