Higher risk in HB is classified by the Children’s Hepatic tumors International Collaboration (CHIC) [55] by several parameters, including histology (pure fetal better than small cell undifferentiated), biological behavior (worse prognosis with lower AFP levels <100 U/mL, spontaneous tumor rupture at involvement or locally advanced tumors with macroscopic vascular invasion and metastatic disease), and age at time of diagnosis [56]. This evidence concerns the gene AFP and neoplasm.