In addition, the miR-215/lysine demethylase 1B (KDM1B) axis was shown to control the hypoxic response and expression of genes involved in glucose metabolism including HIF2α, N-Myc downstream regulated 1 (Ndrg1), adrenomedullin (ADM), NDUFA4 mitochondrial complex associated like 2 (NDUFA4L2), Glut1, and Glut3 in glioma-developing cells. Here, ADM is linked to central nervous system cancer.