Examples include the glycolysis inhibitor 3-bromopyruvate (3-BP), which targets HK-2 and the mitochondrial ATP synthasome [123]; the glucose analog 2-deoxy-d-glucose (2-DG), which depletes tumor cell energy reserves and elicits antitumor effects [124], as well as dichloroacetic acid (DCA), which can minimize the Warburg effect through PDK1 inhibition, thus shifting tumor cells towards OXPHOS for glucose metabolism [125]. This evidence concerns the gene PDK1 and neoplasm.