LAMC2 and cancer: Four different tumor samples were immunostained, and the representative images show that LAMC2 was clearly detected in tumor cells, and was particularly intense in some samples (Figure 2B and Figure S5); the expression pattern of TNC was heterogenous, as in some samples the protein was expressed both in neoplastic cells and in the stroma, while in other samples, cancer cells were negative whereas a strong signal was present in stromal fibers; immunostaining of PTX3 was detected in some cancer cells, and occasionally in stromal cells.