We focused our attention on six proteins: two extracellular matrix (ECM) proteins, i.e., Laminin-C2 (LAMC2) and Tenascin-C (TNC); two proteins related to KRAS activity, i.e., RAS-related Nuclear protein (RAN) and Farnesyl pyrophosphate synthase (FPPS/FDPS); Stanniocalcin2 (STC2), a multifunctional glycoprotein with recently recognized role in cancer; Ubiquitin carboxy-terminal hydrolase L1 (UCHL-1), a deubiquitinating enzyme that was the most consistently upregulated protein among our six KRAS-cloned lines. This evidence concerns the gene KRAS and cancer.