Of these, 23 markers (BAD, BAX, CDH1, CDK6, CDKN1A, CDKN1B, CTNNB1, EGF, EGFR, FN1, HRAS, IRS2, KRAS, MAPK3, MDM2, MMP2, PDGFC, PIK3CA, PIK3R3, SMAD4, TGFB1, TGFBR2, TLR2) have been covered in the literature very widely, and multiple publications link these, largely through mutations, to many different cancers, including CRC. The gene discussed is MDM2; the disease is cancer.