ERBB2 and breast cancer: Moreover, the weighted methylation level of KCNQ1OT1 region 2 was associated with the risk of both the luminal A and HER-2-overexpressing subtypes of BC, with adjusted ORs of 0.446 (95% CI: 0.276–0.706, p < 0.001) and 0.424 (95% CI: 0.176–0.936, p = 0.042), respectively (Table 3).