The genetic alterations in PD-L1 include 9p24.1 gain in lymphomas and gastric adenocarcinomas, PD-L1 3’-UTR disruption in multiple cancers, and CIITA-PD-L1 fusion, which is commonly detected in mediastinal large B-cell lymphoma [18,83,84,85,86,87,88,89,90,91,92,93]. The gene discussed is CD274; the disease is lymphoma.