In accordance with the demonstration that a mild temperature upregulates the expression of PD-L1 in tumor cells [57,58], in TRPV1-positive BC cells, the TRPV1 antagonist CPZ completely reverts the CPS-induced increase in PD-L1, supporting the role of TRPV1 in PD-L1 regulation. This evidence concerns the gene TRPV1 and neoplasm.