Valdez et al. have reported synergistic inhibition of AML and lymphoma cell proliferation by the triple combination of PARPi niraparib, DNMTi decitabine, and HDACi romidepsin or pabinostat, associated with the activation of ATM-mediated DDR, increased ROS production, and the induction of apoptosis [68]. This evidence concerns the gene ATM and acute myeloid leukemia.