myCAFs, with high expression of α-SMA, are located adjacent to cancer cells and produce dense matrices to support tumorigenesis, while iCAFs, with low α-SMA expression, are distal to tumor edges and characterized by secreting inflammatory cytokines, such as IL-6, and consequently induce an immunosuppressive microenvironment [19,41,42,43]. This evidence concerns the gene IL6 and neoplasm.