CD8A and neoplasm: Studies have shown that fibroblasts inhibit platinum aggregation in tumor nuclei by producing cysteine and glutathione, while CD8+ T cells can produce γ-interferon to upregulate γ-glutamyltransferase and inhibit the transcription of xc (−) cystine and glutamate receptors through the JAK/STAT1 pathway, thus controlling the synthesis of glutathione and cysteine in fibroblasts and effectively eliminating chemotherapy resistance in matrices [92].