PFKFB2 and neoplasm: Zhao et al. have reported that CAFs with high expression of CXCL14 could increase the expression of long non-coding RNA LINC00092, which consequently affects glycolysis by binding to the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) glycolytic enzyme and promoting tumor metastasis with the support of surrounding CAFs [60].