For example, many TGF-β signaling-related genes derived from CAFs play important roles in the crosstalk between fibroblasts and ovarian cancer, including periostin (POSTN), collagen type XI alpha 1 (COL11A1), collagen triple helix repeat containing-1 (CTHRC1), and versican (VCAN) [45,46,47,48,64,65,66]. The gene discussed is VCAN; the disease is ovarian cancer.