Significantly, regulators of MPPOL ePGEs, cytokines and MMPs such as p38MAPK and COX-2 are established anti-cancer targets and the elimination of senescent cells by senolytic drugs has been shown to inhibit epidermal SCC progression [59], suggesting that the targeting of MPPOL keratinocytes in a pre-cancerous field could be an effective therapeutic and/or chemotherapeutic strategy. Here, PTGS2 is linked to cancer.